We have only one life but if we’re lucky, we can have a second chance to live a better life, thanks to legal organ transplant and angelic donors. Manipal Hospitals rises to the occasion to provide those who need new organs, the hope of a new life. Our transplant surgeons at the Centre of Excellence of Organ Transplantation are a notch above in this niche and highly distinguished domain. Multi-organ transplant is our forte especially liver transplant, and our team of prolific surgeons are the best in this class.
Organ transplant is no cakewalk and requires high precision skilled techniques in the hands of dedicated expert surgeons. Manipal Hospitals towers above the rest in this domain of expertise. Both paediatric and adult liver transplant procedures get all the best surgical hands on deck, making it the leading quaternary care giant in the country.
A heart transplant is a surgery to remove the diseased heart from a person and replace it with a healthy one from an organ donor. To remove the heart from the donor, two or more healthcare providers must declare the donor brain-dead. Before you can be put on a waiting list for a heart transplant, a cardiologist makes the decision that this is the best…
The liver is one of the most complex organs playing an important role in the quality of life. Liver transplantation restores a better quality of life and helps patients in living healthy. A pancreas transplant is surgery to implant a healthy pancreas from a donor into a person with diabetes. Pancreas transplants give the person a chance to stop taking…
Sometimes it may be necessary to do multi-organ transplants since the liver or kidneys may be affected by a diseased heart. Heart-liver, heart-lung, and heart-kidney transplants are performed when replacing the heart alone may not be enough to save the patient.
Gastrointestinal (GI) cancer is the group of cancers that affect the gastrointestinal tract and other organs that are contained within the digestive system, including the oesophagus, pancreas, stomach, colon, rectum, anus, liver, biliary system, and small intestine. In earlier days, surgery was a unanimous option and considered the chief curative treatment…
In a kidney transplant surgery, a healthy kidney is transplanted from a healthy donor when the patient's kidneys no longer function. Kidney transplant is usually the last and only option for those suffering from end-stage renal failure and have been on haemodialysis. The end-stage renal disease occurs when kidneys lose 90 percent of their normal functional…
Hepato-pancreato-biliary (HPB) surgery involves surgery of liver, pancreas, bile ducts and gall bladder. HPB surgeries involve liver resections for liver cancer and other metastatic liver cancers, bile duct cancers, gall bladder cancers surgery, surgery for pancreatic cancer, Whipple’s resection. Surgeries for benign liver disease as stones in the…
A highly niche and complex surgery extending up to almost 5-6 hours, the Whipple procedure, or pancreaticoduodenectomy, is the most common surgery to remove tumors in the pancreas. This type of surgery involves not only the removal but also the reconstruction of a large part of the gastrointestinal tract.
The spleen is an organ that is located under your rib cage on the upper left side of your abdomen. It helps fight infection and filters waste material such as old or damaged blood cells from your blood. Splenectomy is a surgical procedure to remove your spleen. This is done when the spleen is ruptured, becomes cancerous, contracts idiopathic thrombocytopenic…
Oesophagectomy is a surgical procedure to remove part of the esophagus which is located between your mouth and stomach, and then reconstruct it using some or all of another organ usually the stomach. Gastrectomy is the removal of part or all of the stomach. The types of gastrectomy include partial gastrectomy which is the removal of a part of the stomach,…
Most of the time, oesophagectomy is done to treat cancer of the esophagus. A gastrectomy is often used to treat stomach cancer . There are two types of surgeries - Open gastrectomy is where a large cut is made in your stomach or chest, and keyhole surgery (laparoscopic gastrectomy) – where several smaller cuts are made and special surgical instruments…
Oesophagectomy poses risks that include infection, bleeding, cough, leakage from surgical connection of the esophagus and stomach, hoarseness, acid or bile reflux, respiratory complications, such as pneumonia and swallowing difficulties (dysphagia). Gastrectomy carries a risk of complications, such as infection, bleeding and leaking from the area that's…
Bowel incontinence can vary in severity from passing a small amount of feces when breaking wind to total loss of bowel control. It is common among women as a possible complication of pregnancy. Though not serious, sometimes surgery is the only option when other treatments have failed to treat an underlying condition. Most people need surgery to close…
Sphincteroplasty is a surgery to repair a damaged or weakened anal sphincter. The damaged muscle is removed by the surgeon who then overlaps the muscle edges and sews them back together to provide support to the muscles and tighten the sphincter. Surgery to close a fistula may be done by gynecology and colorectal surgeons jointly. Surgical options…
A fistulotomy is an effective surgical treatment for the removal of anal fistulas and haemorrhoidectomy is the preferred surgery to remove internal or external haemorrhoids that are extensive or severe. Surgical haemorrhoidectomy is the most effective treatment for haemorrhoids.
The most common of all inflammatory bowel diseases are Crohn's disease and ulcerative colitis. Crohn’s disease is a chronic inflammatory disease of the digestive tract and symptoms include abdominal pain and diarrhea, sometimes with blood, and weight loss. Ulcerative colitis occurs when the lining of your large intestine or colon, rectum, or both becomes…
A lung transplant is the last option for those having lung failure from a diseased lung. A new lung can not only save your life but also improve your quality of life after a transplant.
An organ transplant is a surgical procedure where a diseased organ is removed and replaced by a healthy organ through transplantation from either a deceased or a living donor. Manipal Hospitals specialize in heart transplant, lung transplant, kidney transplant, liver transplant, pancreas transplant, bone marrow transplant.
Transplantation medicine is one of the most challenging and complex areas of modern medicine. Some of the key areas for medical management are the problems of transplant rejection, during which the body has an immune response to the transplanted organ, possibly leading to transplant failure and the need to immediately remove the organ from the recipient. When possible, transplant rejection can be reduced through serotyping to determine the most appropriate donor-recipient match and through the use of immunosuppressant drugs.
Manipal Hospitals has a dedicated transplant team who work with patients and their family and discuss their requirements, needs, and lifestyle to determine the most appropriate course of treatment. Manipal Hospitals' organ transplant program is one of the largest of its kind in the country and caters to the following: 1. Heart Transplant 2. Liver Transplant 3. Kidney Transplant 4. Pancreas Transplant 5. Lung Transplant 6. Bone Marrow Transplant
When the patient has decompensated liver cirrhosis with symptoms like Jaundice, Ascites, Pedal Edema, GI Bleed like Blood Vomiting or Blood in Motions, Coagulopathy (Bleeding Tendency), Encephalopathy (Hepatic Coma), Hepatorenal Syndrome (HRS), Hepatic Hydrothorax and Sarcopenia.
The causes of liver failure are different in adults and children.
Causes in adults:
Hepatitis- B cirrhosis.
Hepatitis- C cirrhosis.
NASH + diabetes/obesity-related cirrhosis.
Liver tumors like Hepatocellular carcinoma (HCC).
Intrahepatic cholangiocarcinoma (CCA)
Metastatic neuroendocrine tumors (NET's).
Liver Colorectal Metastasis (LCRM's) if no residual primary.
Causes in children:
Progressive Familial Intrahepatic Cholestasis (PFIC types 1-6).
Metabolic disorders like
Maple syrup urine disease (MSUD)
Glycogen storage disease GSD)
Urea cycle disorders
Liver tumors like Hepatoblastoma
Once diagnosis and requirement for liver transplantation are established then the patient has to undergo thorough liver transplant workup for the assessment of the liver condition and functioning of other organ systems and fitness for anesthesia. Once the patient is worked up he or she will be registered in the Jeevan Daan cadaveric liver transplant program (DDLT), if in case he or she has a suitable living donor in the family we proceed with living donor liver transplantation (LDLT) at the earliest to avoid waiting list mortality in DDLT.
In liver transplantation, the diseased cirrhotic liver is removed completely and a new 'whole liver' in cadaveric and 'part' of the liver in living donor liver transplant is placed at the site of the old liver. The procedure takes around 10 to 15 hours and the post-op patient is kept on ventilator for 1-2 days and complete recovery takes around two weeks.
In the living donor, the surgery takes around 7-9 hours and is discharged in a week's time.
In deceased donor liver transplantation (DDLT) the chances of getting a liver depend on availability and allocation of an organ from brain dead donor and multiple other factors and may not happen in right time hence associated with high waiting list mortality rate. To avoid death during waiting period suitable donor from the family is worked up for a partial liver donation and if found suitable, a part of the liver is taken from the family member.
The liver has a unique capacity to 'regenerate' after cutting hence there are no risks to the donor except he has to undergo major liver surgery with less than <1 % risk of major complications ( Bleeding and bile leak) and 5 to 10% risk of minor complications like weakness and prolonged hospital stay.
Chronic liver failure (CLF)
Acute on chronic liver failure (ACLF)
Acute liver failure (ALF)
Acute liver failure (ALF) is a condition where the liver fails very quickly within 1 -2 days.
The main causes are:
Hepatitis A Virus.
Drug-induced liver injury (DILI).
The main symptoms are Coagulopathy (Bleeding Tendency) and Encephalopathy (Coma) leading to cerebral oedema and death if a liver transplant is not done at the right time.
Certainly yes, as we know there are many causes of liver failure in children so liver transplantation in children is a well-established modality of treating liver failure. In children, it's usually a living donor liver transplant (LDLT) where the donor is either mother or father or any family member and very rarely if we get a part of a liver from a cadaver we can do a split liver transplant (SLT) where a cadaveric liver is split into two and one big part is given to an adult recipient and a small part is given to a child.
At Manipal Hospitals, Vijayawada, we have done around 40 liver transplants in which 35 are cadaveric liver transplant and 5 are living donor liver transplant in which 3 are children that is pediatric living donor liver transplantation and luckily 95% of our patients are alive in the
Organ transplantation is the patient's choice, but a new organ is a gift of life that needs to be respected and cared with appreciation. Contact us to know more about organ transplants and book an appointment with us today.